| Card | Set | Grade | Value | PSA 10 pop | Gem rate |
|---|
| Mewtwo Star #103 | Holon Phantoms 2006 | PSA 10 | $204,767 | 127 | 5.9% |
| Mewtwo-EX #98 | Next Destinies 2012 | PSA 10 | $115,000 | 13 | 2.1% |
| Mewtwo #20 | Expedition Base Set 2002 | PSA 10 | $100,367 | 62 | 3.8% |
| Rocket's Mewtwo ex #99 | Team Rocket Returns 2004 | PSA 10 | $68,500 | 84 | 6.4% |
| Mewtwo #11 | Legends Awakened 2008 | PSA 10 | $32,050 | 9 | 2.2% |
| Shining Mewtwo #109 | Neo Destiny 2002 | PSA 10 | $20,600 | 299 | 6.5% |
| Mewtwo δ #12 | Delta Species 2005 | PSA 10 | $19,137 | 85 | 6.3% |
| Mewtwo #144 | Legends Awakened 2008 | PSA 10 | $18,450 | — | — |
| Mewtwo EX #163 | BREAKthrough 2015 | PSA 10 | $12,267 | 235 | 7.6% |
| Mewtwo EX #157 | BREAKthrough 2015 | PSA 10 | $11,441 | 260 | 11% |
| Mewtwo EX #164 | BREAKthrough 2015 | PSA 10 | $10,917 | 262 | 8.2% |
| Mewtwo EX XY125 | XY Black Star Promos 2013 | PSA 10 | $10,898 | 49 | 3.5% |
| Mewtwo EX #158 | BREAKthrough 2015 | PSA 10 | $8,433 | 400 | 17% |
| Mewtwo XY101 | XY Black Star Promos 2013 | PSA 10 | $7,600 | 9 | 2.5% |
| Mewtwo DP28 | DP Black Star Promos 2007 | PSA 10 | $7,387 | 6 | 0.6% |
| Mewtwo SM77 | SM Black Star Promos 2017 | PSA 10 | $6,200 | — | — |
| Rocket's Mewtwo #14 | Gym Challenge 2000 | PSA 10 | $6,100 | 73 | 1.8% |
| Mewtwo #10 | Base Set 1999 | PSA 10 | $5,562 | 7 | 1.8% |
| Mewtwo #10 | Base Set 2 2000 | PSA 10 | $5,412 | 80 | 1.8% |
| Mewtwo #12 | Wizards Black Star Promos 1999 | PSA 10 | $4,800 | 289 | 14% |
| M Mewtwo EX #160 | BREAKthrough 2015 | PSA 10 | $4,325 | 519 | 16% |
| M Mewtwo EX #159 | BREAKthrough 2015 | PSA 10 | $4,267 | 543 | 17% |
| Mewtwo δ #24 | Holon Phantoms 2006 | PSA 10 | $3,481 | 65 | 16% |
| Mewtwo-EX BW45 | BW Black Star Promos 2011 | PSA 10 | $3,330 | 15 | 5.2% |
| Mewtwo #14 | Wizards Black Star Promos 1999 | PSA 10 | $2,406 | 321 | 7.4% |
| Mewtwo #29 | Legendary Collection 2002 | PSA 10 | $2,234 | 94 | 21% |
| Mewtwo SM214 | SM Black Star Promos 2017 | PSA 10 | $2,142 | 166 | 16% |
| Mewtwo #56 | Expedition Base Set 2002 | PSA 10 | $2,100 | 142 | 23% |
| Mewtwo #9 | Majestic Dawn 2008 | PSA 10 | $2,078 | 9 | 2.3% |
| Mewtwo EX #61 | BREAKthrough 2015 | PSA 10 | $2,033 | 0 | 0.0% |
| Mewtwo EX XY107 | XY Black Star Promos 2013 | PSA 10 | $2,032 | 206 | 26% |
| Mewtwo & Mew GX #242 | Unified Minds 2019 | PSA 10 | $1,767 | 1,203 | 43% |
| Mewtwo & Mew GX #222 | Unified Minds 2019 | PSA 10 | $1,632 | 684 | 35% |
| Mewtwo #3 | Wizards Black Star Promos 1999 | PSA 10 | $1,627 | — | — |
| Mewtwo-EX XY183 | XY Black Star Promos 2013 | PSA 10 | $1,608 | 55 | 11% |
| M Mewtwo EX #64 | BREAKthrough 2015 | PSA 10 | $1,374 | 0 | 0.0% |
| M Mewtwo EX #63 | BREAKthrough 2015 | PSA 10 | $1,300 | 0 | 0.0% |
| Mewtwo #12 | Detective Pikachu 2019 | PSA 10 | $1,163 | 251 | 24% |
| Mewtwo & Mew GX #71 | Unified Minds 2019 | PSA 10 | $907 | 2,575 | 42% |
| Mewtwo & Mew GX #71 | 2019 World Championships Deck: Perfection 2019 | PSA 10 | $871 | 2,575 | 42% |
| Mewtwo EX #103 | Evolutions 2016 | PSA 10 | $800 | 3,139 | 29% |
| Rocket's Mewtwo ex #231 | Destined Rivals 2025 | PSA 10 | $782 | 10,706 | 57% |
| Mewtwo EX #62 | BREAKthrough 2015 | PSA 10 | $765 | 208 | 27% |
| Mewtwo #51 | Evolutions 2016 | PSA 10 | $466 | 892 | 24% |
| Mewtwo V SWSH223 | SWSH Black Star Promos 2019 | PSA 10 | $407 | 134 | 28% |
| Mewtwo-GX SV59 | Hidden Fates Shiny Vault 2019 | PSA 10 | $374 | 7,221 | 54% |
| Rocket's Mewtwo ex #281 | Ascended Heroes 2026 | PSA 10 | $356 | 7,434 | 67% |
| Mewtwo ex #151 | 30th Celebration 2026 | PSA 10 | $350 | — | — |
| Mewtwo EX #52 | Evolutions 2016 | PSA 10 | $301 | 0 | 0.0% |
| Mewtwo ex #157 | 30th Celebration 2026 | PSA 10 | $290 | — | — |
| Mewtwo V #072 | Pokémon GO 2022 | PSA 10 | $290 | 7,822 | 49% |
| Mewtwo V #030 | Pokémon GO 2022 | PSA 10 | $283 | 528 | 35% |
| Mewtwo XY100 | XY Black Star Promos 2013 | PSA 10 | $250 | 7 | 2.3% |
| Mewtwo VSTAR #079 | Pokémon GO 2022 | PSA 10 | $180 | 3,560 | 58% |
| Mewtwo VSTAR #086 | Pokémon GO 2022 | PSA 10 | $170 | 2,949 | 53% |
| Team Rocket's Mewtwo ex #240 | Destined Rivals 2025 | PSA 10 | $140 | 6,111 | 61% |
| Mewtwo V SWSH229 | SWSH Black Star Promos 2019 | PSA 10 | $137 | 3,589 | 52% |
| Mewtwo VSTAR #031 | Pokémon GO 2022 | PSA 10 | $122 | 1,303 | 50% |
| Mewtwo GX #31 | Hidden Fates 2019 | PSA 10 | $122 | 4,298 | 58% |
| TEAM Rocket's Mewtwo ex #213 | Destined Rivals 2025 | PSA 10 | $94.00 | 8,813 | 64% |
| Mewtwo V #030 | Go Japanese 2022 | PSA 10 | $59.00 | 1,340 | 79% |
